Drug interactions
Antipyrine + Cimetidine
Severity: Minor
Antipyrine and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine reduces the hepatic clearance of antipyrine, prolonging its half-life. This has been used in research on liver metabolism and has little therapeutic relevance.
What this interaction means in plain words
Antipyrine and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine inhibits several CYP enzymes involved in antipyrine metabolism, including CYP1A2.
What to do
No action is needed in practice. Interpret antipyrine clearance tests with awareness of cimetidine use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Antipyrine and Cimetidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Antipyrine with Cimetidine?
MediHelp rates the interaction as minor. Antipyrine and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine reduces the hepatic clearance of antipyrine, prolonging its half-life. This has been used in research on liver metabolism and has little therapeutic relevance.
How serious is the interaction between Antipyrine and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed in practice. Interpret antipyrine clearance tests with awareness of cimetidine use.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
