Drug interactions
cimetidine + dofetilide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ dofetilide levels → torsades risk; contraindicated.
Mechanism of action
Renal cation transporter inhibition.
Clinical management
Contraindicated; use alternative to cimetidine.
Drug reference
References
Frequently asked questions
Can I take cimetidine with dofetilide?
The interaction is rated: Contraindicated. ↑ dofetilide levels → torsades risk; contraindicated.
How serious is the interaction between cimetidine and dofetilide?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between cimetidine and dofetilide managed?
Contraindicated; use alternative to cimetidine.
Why do cimetidine and dofetilide interact?
Renal cation transporter inhibition.
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