Drug interactions
Cimetidine + Fezolinetant
Severity: Contraindicated
Cimetidine and Fezolinetant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine inhibits CYP1A2 and can increase fezolinetant exposure, raising the risk of adverse effects including liver enzyme elevation. Fezolinetant labeling contraindicates concomitant CYP1A2 inhibitors.
What this interaction means in plain words
Cimetidine and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cimetidine belongs to Gastrointestinal Tract; Fezolinetant belongs to Endocrine.
Why it happens
Inhibition of CYP1A2-mediated metabolism of fezolinetant increases its plasma concentrations.
What to do
Do not combine; use famotidine or another non-CYP1A2-inhibiting acid suppressant. Monitor liver tests if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
- Cimetidine + Clozapine Major
Other interactions of Fezolinetant
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
Frequently asked questions
Can I take Cimetidine with Fezolinetant?
MediHelp rates the interaction as contraindicated. Cimetidine and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cimetidine inhibits CYP1A2 and can increase fezolinetant exposure, raising the risk of adverse effects including liver enzyme elevation. Fezolinetant labeling contraindicates concomitant CYP1A2 inhibitors.
How serious is the interaction between Cimetidine and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use famotidine or another non-CYP1A2-inhibiting acid suppressant. Monitor liver tests if exposure occurs.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Alfentanil, Atazanavir. The full list is on the Cimetidine page.
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