Drug interactions
Antipyrine + Mexiletine
Severity: Minor
Antipyrine and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipyrine is a probe substrate of several CYP enzymes, and mexiletine inhibits CYP1A2, which may slow antipyrine clearance. Antipyrine is rarely used therapeutically, so the impact is minor.
What this interaction means in plain words
Antipyrine and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mexiletine inhibits CYP1A2, reducing antipyrine metabolism.
What to do
No specific action is needed. Take the effect into account if antipyrine clearance is used as a metabolic test.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Antipyrine with Mexiletine?
MediHelp rates the interaction as minor. Antipyrine and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipyrine is a probe substrate of several CYP enzymes, and mexiletine inhibits CYP1A2, which may slow antipyrine clearance. Antipyrine is rarely used therapeutically, so the impact is minor.
How serious is the interaction between Antipyrine and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Take the effect into account if antipyrine clearance is used as a metabolic test.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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