Drug interactions
Fezolinetant + Mexiletine
Severity: Contraindicated
Fezolinetant and Mexiletine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fezolinetant is metabolized primarily by CYP1A2, and its exposure rises with CYP1A2 inhibitors. Mexiletine is a CYP1A2 inhibitor, so fezolinetant levels may increase, raising the risk of liver toxicity and other adverse effects. Labeling contraindicates use with CYP1A2 inhibitors.
What this interaction means in plain words
Fezolinetant and Mexiletine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fezolinetant belongs to Endocrine; Mexiletine belongs to Cardiovascular.
Why it happens
Mexiletine inhibits CYP1A2, reducing fezolinetant clearance.
What to do
Do not use together; choose another menopause vasomotor therapy. If mexiletine is required, stop fezolinetant.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mexiletine
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
- Dofetilide + Mexiletine Major
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
Frequently asked questions
Can I take Fezolinetant with Mexiletine?
MediHelp rates the interaction as contraindicated. Fezolinetant and Mexiletine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized primarily by CYP1A2, and its exposure rises with CYP1A2 inhibitors. Mexiletine is a CYP1A2 inhibitor, so fezolinetant levels may increase, raising the risk of liver toxicity and other adverse effects. Labeling contraindicates use with CYP1A2 inhibitors.
How serious is the interaction between Fezolinetant and Mexiletine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose another menopause vasomotor therapy. If mexiletine is required, stop fezolinetant.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Pimozide, Alosetron, Amiodarone. The full list is on the Mexiletine page.
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