Drug reference
mexiletine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Arrhythmia)
Mechanism of action
Class 1B antidysrhythmic; combines with fast Na channels & thereby inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity
Common side effects
- Dizziness
- Vomiting
- Nausea
- Ataxia
- Heartburn
Boxed warnings
- National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction (MI) >6 days but <2 yr previously Average duration of treatment w/ encainide or flecainide in CAST was 10 months Applicability of CAST results to other populations (eg, patients without recent MI) is uncertain…
Contraindications
- Hypersensitivity to mexiletine Cardiogenic shock, preexisting 2°/3° AV block without pacemaker
Known interactions (1)
- duloxetine + mexiletine Moderate
Related conditions
Frequently asked questions
What drug class is mexiletine?
mexiletine belongs to: Cardiovascular.
How does mexiletine work?
Class 1B antidysrhythmic; combines with fast Na channels & thereby inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity
What are the common side effects of mexiletine?
Dizziness, Vomiting, Nausea, Ataxia, Heartburn
Which drugs interact with mexiletine?
duloxetine
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