Drug interactions
Antipyrine + Secobarbital
Severity: Minor
Antipyrine and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic drug-metabolizing enzymes and shorten antipyrine half-life. Antipyrine is mainly used as a probe of metabolic capacity, so the effect is of little clinical consequence.
What this interaction means in plain words
Antipyrine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hepatic microsomal enzyme induction by secobarbital increases antipyrine clearance.
What to do
No action is generally required; interpret antipyrine clearance tests with awareness of enzyme induction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Antipyrine with Secobarbital?
MediHelp rates the interaction as minor. Antipyrine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic drug-metabolizing enzymes and shorten antipyrine half-life. Antipyrine is mainly used as a probe of metabolic capacity, so the effect is of little clinical consequence.
How serious is the interaction between Antipyrine and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; interpret antipyrine clearance tests with awareness of enzyme induction.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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