Drug interactions
Antithrombin alfa + Apixaban
Severity: Major
Antithrombin alfa and Apixaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates inactivation of thrombin and factor Xa, adding to apixaban's anticoagulation. This increases bleeding risk.
What this interaction means in plain words
Antithrombin alfa and Apixaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive anticoagulant pharmacodynamic effects.
What to do
Avoid combining where possible; if both are required, monitor closely for bleeding and consider holding apixaban during antithrombin therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Antithrombin alfa with Apixaban?
MediHelp rates the interaction as major. Antithrombin alfa and Apixaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithrombin alfa potentiates inactivation of thrombin and factor Xa, adding to apixaban's anticoagulation. This increases bleeding risk.
How serious is the interaction between Antithrombin alfa and Apixaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are required, monitor closely for bleeding and consider holding apixaban during antithrombin therapy.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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