Drug interactions
Antithrombin alfa + Argatroban
Severity: Moderate
Antithrombin alfa and Argatroban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa enhances inhibition of thrombin and factor Xa, and argatroban directly inhibits thrombin, so the anticoagulant effects add together. This increases the risk of bleeding.
What this interaction means in plain words
Antithrombin alfa and Argatroban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic anticoagulation through complementary thrombin inhibition.
What to do
Monitor aPTT or ACT and for signs of bleeding, adjusting argatroban dose accordingly. Use the combination only when clearly indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Antithrombin alfa with Argatroban?
MediHelp rates the interaction as moderate. Antithrombin alfa and Argatroban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa enhances inhibition of thrombin and factor Xa, and argatroban directly inhibits thrombin, so the anticoagulant effects add together. This increases the risk of bleeding.
How serious is the interaction between Antithrombin alfa and Argatroban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or ACT and for signs of bleeding, adjusting argatroban dose accordingly. Use the combination only when clearly indicated.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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