Drug interactions
Antithrombin alfa + Celecoxib
Severity: Moderate
Antithrombin alfa and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin and inhibits clotting factors, while celecoxib has modest antiplatelet effects and can cause gastrointestinal bleeding. Combined use may add to bleeding risk, particularly with concurrent heparin.
What this interaction means in plain words
Antithrombin alfa and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis: coagulation inhibition plus NSAID-related platelet and mucosal effects.
What to do
Monitor for bleeding and hemoglobin, and consider whether an NSAID is necessary. Use gastroprotection in patients at high gastrointestinal risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Antithrombin alfa with Celecoxib?
MediHelp rates the interaction as moderate. Antithrombin alfa and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin and inhibits clotting factors, while celecoxib has modest antiplatelet effects and can cause gastrointestinal bleeding. Combined use may add to bleeding risk, particularly with concurrent heparin.
How serious is the interaction between Antithrombin alfa and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin, and consider whether an NSAID is necessary. Use gastroprotection in patients at high gastrointestinal risk.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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