Drug interactions
Antithrombin alfa + Cilostazol
Severity: Moderate
Antithrombin alfa and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and cilostazol impairs platelet aggregation. Together they may increase bleeding risk, though the interaction is mostly predicted.
What this interaction means in plain words
Antithrombin alfa and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from anticoagulant activity and PDE3-mediated platelet inhibition.
What to do
Monitor for bleeding and coagulation parameters (anti-Xa or aPTT as appropriate) during antithrombin treatment. Consider holding cilostazol in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Antithrombin alfa with Cilostazol?
MediHelp rates the interaction as moderate. Antithrombin alfa and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and cilostazol impairs platelet aggregation. Together they may increase bleeding risk, though the interaction is mostly predicted.
How serious is the interaction between Antithrombin alfa and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters (anti-Xa or aPTT as appropriate) during antithrombin treatment. Consider holding cilostazol in patients at high bleeding risk.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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