Drug interactions
Antithrombin alfa + Clopidogrel
Severity: Moderate
Antithrombin alfa and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin and thrombin inhibition, and combined with clopidogrel it adds to hemorrhage risk. The combination is not absolutely forbidden and is used in clinical practice with caution.
What this interaction means in plain words
Antithrombin alfa and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticoagulant and antiplatelet effects.
What to do
Monitor for bleeding and follow coagulation parameters such as anti-Xa or aPTT if heparin is also used. Adjust dosing according to the clinical situation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Antithrombin alfa with Clopidogrel?
MediHelp rates the interaction as moderate. Antithrombin alfa and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin and thrombin inhibition, and combined with clopidogrel it adds to hemorrhage risk. The combination is not absolutely forbidden and is used in clinical practice with caution.
How serious is the interaction between Antithrombin alfa and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow coagulation parameters such as anti-Xa or aPTT if heparin is also used. Adjust dosing according to the clinical situation.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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