Drug interactions
Antithrombin alfa + Diclofenac
Severity: Moderate
Antithrombin alfa and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates heparin anticoagulation, and diclofenac inhibits platelet function and can injure the GI mucosa. Together bleeding risk may rise.
What this interaction means in plain words
Antithrombin alfa and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on hemostasis: anticoagulant plus NSAID antiplatelet and mucosal effects.
What to do
Avoid concurrent NSAID where possible. If used, monitor for bleeding and coagulation parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Antithrombin alfa with Diclofenac?
MediHelp rates the interaction as moderate. Antithrombin alfa and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa potentiates heparin anticoagulation, and diclofenac inhibits platelet function and can injure the GI mucosa. Together bleeding risk may rise.
How serious is the interaction between Antithrombin alfa and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID where possible. If used, monitor for bleeding and coagulation parameters.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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