Drug interactions
Antithrombin alfa + Diflunisal
Severity: Moderate
Antithrombin alfa and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin anticoagulation, and diflunisal impairs platelet function and can injure the GI mucosa, so bleeding risk rises. The effect is pharmacodynamic.
What this interaction means in plain words
Antithrombin alfa and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from anticoagulant activity and NSAID-induced platelet inhibition.
What to do
Monitor for bleeding signs and coagulation parameters such as aPTT or anti-Xa. Prefer acetaminophen for analgesia when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Antithrombin alfa with Diflunisal?
MediHelp rates the interaction as moderate. Antithrombin alfa and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin anticoagulation, and diflunisal impairs platelet function and can injure the GI mucosa, so bleeding risk rises. The effect is pharmacodynamic.
How serious is the interaction between Antithrombin alfa and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and coagulation parameters such as aPTT or anti-Xa. Prefer acetaminophen for analgesia when possible.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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