Drug interactions
Antithrombin alfa + Etodolac
Severity: Moderate
Antithrombin alfa and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and etodolac impairs platelet function and can cause gastrointestinal mucosal injury. Together they may increase the risk of bleeding.
What this interaction means in plain words
Antithrombin alfa and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: enhanced inhibition of coagulation factors plus NSAID antiplatelet effect.
What to do
Monitor for signs of bleeding and relevant coagulation parameters during co-use. Consider gastroprotection or a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Antithrombin alfa with Etodolac?
MediHelp rates the interaction as moderate. Antithrombin alfa and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and etodolac impairs platelet function and can cause gastrointestinal mucosal injury. Together they may increase the risk of bleeding.
How serious is the interaction between Antithrombin alfa and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and relevant coagulation parameters during co-use. Consider gastroprotection or a non-NSAID analgesic.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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