Drug interactions
Antithrombin alfa + Indomethacin
Severity: Moderate
Antithrombin alfa and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and indomethacin impairs platelet function and can injure the GI mucosa. Together they raise the risk of bleeding.
What this interaction means in plain words
Antithrombin alfa and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: antithrombin-mediated inhibition of clotting factors plus NSAID platelet inhibition.
What to do
Monitor for bleeding and coagulation parameters such as aPTT or anti-Xa, and consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Antithrombin alfa with Indomethacin?
MediHelp rates the interaction as moderate. Antithrombin alfa and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and indomethacin impairs platelet function and can injure the GI mucosa. Together they raise the risk of bleeding.
How serious is the interaction between Antithrombin alfa and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters such as aPTT or anti-Xa, and consider an alternative analgesic.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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