Drug interactions
Antithrombin alfa + Oxaprozin
Severity: Moderate
Antithrombin alfa and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates heparin-mediated anticoagulation, and oxaprozin impairs platelet function and can injure the gastric mucosa. Combined use raises the risk of clinically significant bleeding.
What this interaction means in plain words
Antithrombin alfa and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic additive effect: antithrombin-driven inhibition of coagulation factors plus NSAID platelet inhibition and mucosal injury.
What to do
Avoid NSAIDs where possible during antithrombin therapy. If they are needed, monitor for bleeding, hemoglobin and coagulation parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Antithrombin alfa with Oxaprozin?
MediHelp rates the interaction as moderate. Antithrombin alfa and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa potentiates heparin-mediated anticoagulation, and oxaprozin impairs platelet function and can injure the gastric mucosa. Combined use raises the risk of clinically significant bleeding.
How serious is the interaction between Antithrombin alfa and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during antithrombin therapy. If they are needed, monitor for bleeding, hemoglobin and coagulation parameters.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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