Drug interactions
Antithrombin alfa + Prednisone
Severity: Moderate
Antithrombin alfa and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter coagulation, and may either raise coagulability or weaken vascular integrity and increase bleeding risk. The net effect on antithrombin's anticoagulant activity is unpredictable.
What this interaction means in plain words
Antithrombin alfa and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: corticosteroid effects on coagulation factors and vascular fragility may oppose or add to antithrombin activity; the mechanism is not firmly established.
What to do
Monitor coagulation parameters appropriate to the treatment (such as anti-Xa or aPTT and antithrombin activity) and watch for bleeding or thrombosis. Adjust antithrombin dosing based on results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Antithrombin alfa with Prednisone?
MediHelp rates the interaction as moderate. Antithrombin alfa and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter coagulation, and may either raise coagulability or weaken vascular integrity and increase bleeding risk. The net effect on antithrombin's anticoagulant activity is unpredictable.
How serious is the interaction between Antithrombin alfa and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters appropriate to the treatment (such as anti-Xa or aPTT and antithrombin activity) and watch for bleeding or thrombosis. Adjust antithrombin dosing based on results.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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