Drug interactions
Antithrombin alfa + Sulindac
Severity: Moderate
Antithrombin alfa and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa potentiates heparin-type anticoagulation, while sulindac impairs platelet function and can cause gastrointestinal lesions. Together they increase the risk of bleeding.
What this interaction means in plain words
Antithrombin alfa and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from anticoagulant activity and NSAID platelet inhibition.
What to do
Avoid NSAIDs where possible during antithrombin therapy. If needed, monitor for bleeding and coagulation parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Antithrombin alfa with Sulindac?
MediHelp rates the interaction as moderate. Antithrombin alfa and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa potentiates heparin-type anticoagulation, while sulindac impairs platelet function and can cause gastrointestinal lesions. Together they increase the risk of bleeding.
How serious is the interaction between Antithrombin alfa and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during antithrombin therapy. If needed, monitor for bleeding and coagulation parameters.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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