Drug interactions
Antithrombin alfa + Ticagrelor
Severity: Moderate
Antithrombin alfa and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates anticoagulation, mainly through heparin-like pathways, while ticagrelor inhibits platelet aggregation. Combined use increases the risk of bleeding.
What this interaction means in plain words
Antithrombin alfa and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from P2Y12 platelet inhibition and enhanced anticoagulation.
What to do
Monitor for bleeding and coagulation parameters such as anti-Xa or aPTT as appropriate. Adjust anticoagulant dosing if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Antithrombin alfa with Ticagrelor?
MediHelp rates the interaction as moderate. Antithrombin alfa and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates anticoagulation, mainly through heparin-like pathways, while ticagrelor inhibits platelet aggregation. Combined use increases the risk of bleeding.
How serious is the interaction between Antithrombin alfa and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters such as anti-Xa or aPTT as appropriate. Adjust anticoagulant dosing if bleeding occurs.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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