Drug reference
ticagrelor
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Platelets)
Mechanism of action
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation, Ticagrelor and its active metabolite are approximately equipotent, Patients can be transitioned from clopidogrel to ticagrelor without interruption of antiplatelet effect
Common side effects
- Dizziness
- Nausea
- Bleeding
- Dyspnea
- Ventricular pauses
- Diarrhea
Boxed warnings
- Bleeding risk Like other antiplatelet agents, can cause significant, sometimes fatal, bleeding Do not use with active pathological bleeding or a history of intracranial hemorrhage Do not start in patients planned to undergo urgent coronary artery bypass graft surgery (CABG); when possible, discontinue at least 5 days prior to any surgery Suspect bleeding in any patient who is hypotensive and has recently undergone coronary angiography, percutaneous coronary intervention (PCI), CABG, or other surgical procedures after starting ticagrelor If possible, manage bleeding without disc…
Contraindications
- History of intracranial hemorrhage (ICH) Active pathologic bleeding (eg, peptic ulcer, ICH)
Known interactions (4)
- itraconazole + ticagrelor Contraindicated
- ketoconazole + ticagrelor Contraindicated
- rifampin + ticagrelor Major
- flibanserin + ticagrelor Moderate
Related conditions
Frequently asked questions
What drug class is ticagrelor?
ticagrelor belongs to: Cardiovascular.
How does ticagrelor work?
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation, Ticagrelor and its active metabolite are approximately equipotent, Patients can be transitioned from clopidogrel to ticagrelor without interruption of antiplatelet effect
What are the common side effects of ticagrelor?
Dizziness, Nausea, Bleeding, Dyspnea, Ventricular pauses, Diarrhea
Which drugs interact with ticagrelor?
itraconazole, ketoconazole, rifampin, flibanserin
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.