Drug interactions
Levoketoconazole + Ticagrelor
Severity: Contraindicated
Levoketoconazole and Ticagrelor: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A inhibitor and is expected to markedly increase ticagrelor exposure, raising bleeding risk. Strong CYP3A inhibitors such as ketoconazole are not recommended with ticagrelor.
What this interaction means in plain words
Levoketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Ticagrelor belongs to Cardiovascular.
Why it happens
Strong CYP3A4 inhibition reduces ticagrelor clearance.
What to do
Avoid the combination and choose an alternative antiplatelet. If antifungal or cortisol-lowering therapy is needed, consider an option without strong CYP3A inhibition.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
- Acetylsalicylic acid + Ticagrelor Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Ticagrelor?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A inhibitor and is expected to markedly increase ticagrelor exposure, raising bleeding risk. Strong CYP3A inhibitors such as ketoconazole are not recommended with ticagrelor.
How serious is the interaction between Levoketoconazole and Ticagrelor?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiplatelet. If antifungal or cortisol-lowering therapy is needed, consider an option without strong CYP3A inhibition.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Abciximab. The full list is on the Ticagrelor page.
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