Drug interactions
Antithrombin iii + Argatroban
Severity: Moderate
Antithrombin iii and Argatroban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III potentiates endogenous inhibition of thrombin and factor Xa, while argatroban inhibits thrombin directly, so the combined anticoagulant effect is greater. Bleeding risk is increased.
What this interaction means in plain words
Antithrombin iii and Argatroban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic anticoagulation through complementary thrombin inhibition.
What to do
Monitor aPTT or ACT and for bleeding, and reduce the argatroban dose if clotting times are excessively prolonged. Avoid the combination unless clearly indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Antithrombin iii with Argatroban?
MediHelp rates the interaction as moderate. Antithrombin iii and Argatroban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III potentiates endogenous inhibition of thrombin and factor Xa, while argatroban inhibits thrombin directly, so the combined anticoagulant effect is greater. Bleeding risk is increased.
How serious is the interaction between Antithrombin iii and Argatroban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or ACT and for bleeding, and reduce the argatroban dose if clotting times are excessively prolonged. Avoid the combination unless clearly indicated.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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