Drug interactions
Antithrombin iii + Cilostazol
Severity: Moderate
Antithrombin iii and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances the effect of heparin and related anticoagulants, and cilostazol inhibits platelet function. The combination may raise the risk of bleeding, although direct data are limited.
What this interaction means in plain words
Antithrombin iii and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from enhanced anticoagulant activity and PDE3-mediated platelet inhibition.
What to do
Monitor for bleeding and coagulation parameters during treatment. Consider holding cilostazol in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Antithrombin iii with Cilostazol?
MediHelp rates the interaction as moderate. Antithrombin iii and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances the effect of heparin and related anticoagulants, and cilostazol inhibits platelet function. The combination may raise the risk of bleeding, although direct data are limited.
How serious is the interaction between Antithrombin iii and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters during treatment. Consider holding cilostazol in patients at high bleeding risk.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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