Drug interactions
Antithrombin iii + Diclofenac
Severity: Moderate
Antithrombin iii and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances heparin-type anticoagulation, and diclofenac impairs platelet function and can cause GI bleeding. The combination may increase the risk of hemorrhage.
What this interaction means in plain words
Antithrombin iii and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis from anticoagulation and NSAID antiplatelet activity.
What to do
Avoid NSAIDs where an alternative analgesic is possible. If used together, monitor for bleeding and coagulation tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Antithrombin iii with Diclofenac?
MediHelp rates the interaction as moderate. Antithrombin iii and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances heparin-type anticoagulation, and diclofenac impairs platelet function and can cause GI bleeding. The combination may increase the risk of hemorrhage.
How serious is the interaction between Antithrombin iii and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where an alternative analgesic is possible. If used together, monitor for bleeding and coagulation tests.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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