Drug interactions
Antithrombin iii + Oxaprozin
Severity: Moderate
Antithrombin iii and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of thrombin and factor Xa, particularly with heparin, while oxaprozin impairs platelet function and can cause GI lesions. The combination increases the chance of bleeding.
What this interaction means in plain words
Antithrombin iii and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect between enhanced anticoagulation and NSAID antiplatelet and mucosal-damaging effects.
What to do
Avoid NSAIDs where possible during antithrombin replacement. If they are needed, monitor for bleeding and check coagulation tests and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Antithrombin iii with Oxaprozin?
MediHelp rates the interaction as moderate. Antithrombin iii and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of thrombin and factor Xa, particularly with heparin, while oxaprozin impairs platelet function and can cause GI lesions. The combination increases the chance of bleeding.
How serious is the interaction between Antithrombin iii and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during antithrombin replacement. If they are needed, monitor for bleeding and check coagulation tests and hemoglobin.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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