Drug interactions
Antithrombin iii + Vitamin e
Severity: Minor
Antithrombin iii and Vitamin e: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III potentiates heparin-mediated anticoagulation, and very high doses of vitamin E may modestly impair clotting. Combined use could theoretically increase bleeding tendency, but this is unlikely at ordinary intakes.
What this interaction means in plain words
Antithrombin iii and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive anticoagulant effect, as high-dose vitamin E antagonizes vitamin K-dependent clotting and inhibits platelets.
What to do
Avoid megadose vitamin E during antithrombin therapy. Monitor for bleeding and coagulation parameters as per routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin e
- Betrixaban + Vitamin e Moderate
- Phenindione + Vitamin e Moderate
- Selumetinib + Vitamin e Moderate
- Vitamin e + Warfarin Moderate
- Alfalfa + Vitamin e Minor
- Antithrombin alfa + Vitamin e Minor
Frequently asked questions
Can I take Antithrombin iii with Vitamin e?
MediHelp rates the interaction as minor. Antithrombin iii and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antithrombin III potentiates heparin-mediated anticoagulation, and very high doses of vitamin E may modestly impair clotting. Combined use could theoretically increase bleeding tendency, but this is unlikely at ordinary intakes.
How serious is the interaction between Antithrombin iii and Vitamin e?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid megadose vitamin E during antithrombin therapy. Monitor for bleeding and coagulation parameters as per routine care.
What other medicines interact with Vitamin e?
MediHelp also lists interactions of Vitamin e with, for example, Betrixaban, Phenindione, Selumetinib. The full list is on the Vitamin e page.
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