Drug interactions
Betrixaban + Vitamin e
Severity: Moderate
Betrixaban and Vitamin e: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose vitamin E has antiplatelet and vitamin K antagonistic effects that may raise bleeding tendency. When taken with the factor Xa inhibitor betrixaban, bleeding risk could increase.
What this interaction means in plain words
Betrixaban and Vitamin e can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis from vitamin E's antiplatelet activity and betrixaban's factor Xa inhibition.
What to do
Avoid high-dose vitamin E supplementation in patients on betrixaban unless clearly indicated. Monitor for bruising and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin e
- Phenindione + Vitamin e Moderate
- Selumetinib + Vitamin e Moderate
- Vitamin e + Warfarin Moderate
- Alfalfa + Vitamin e Minor
- Antithrombin alfa + Vitamin e Minor
- Antithrombin iii + Vitamin e Minor
Frequently asked questions
Can I take Betrixaban with Vitamin e?
MediHelp rates the interaction as moderate. Betrixaban and Vitamin e can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose vitamin E has antiplatelet and vitamin K antagonistic effects that may raise bleeding tendency. When taken with the factor Xa inhibitor betrixaban, bleeding risk could increase.
How serious is the interaction between Betrixaban and Vitamin e?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose vitamin E supplementation in patients on betrixaban unless clearly indicated. Monitor for bruising and bleeding.
What other medicines interact with Vitamin e?
MediHelp also lists interactions of Vitamin e with, for example, Phenindione, Selumetinib, Warfarin. The full list is on the Vitamin e page.
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