Drug interactions
Vitamin e + Warfarin
Severity: Moderate
Vitamin e and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose vitamin E may antagonize vitamin K-dependent clotting and has antiplatelet effects, potentially raising INR and bleeding risk. Typical dietary doses rarely matter.
What this interaction means in plain words
Vitamin e and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vitamin e belongs to Gastrointestinal Tract; Warfarin belongs to Cardiovascular.
Why it happens
High-dose vitamin E may inhibit vitamin K-dependent carboxylation and platelet aggregation.
What to do
Avoid high-dose supplements; monitor INR when vitamin E intake changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Vitamin e
- Betrixaban + Vitamin e Moderate
- Phenindione + Vitamin e Moderate
- Selumetinib + Vitamin e Moderate
- Alfalfa + Vitamin e Minor
- Antithrombin alfa + Vitamin e Minor
- Antithrombin iii + Vitamin e Minor
Frequently asked questions
Can I take Vitamin e with Warfarin?
MediHelp rates the interaction as moderate. Vitamin e and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose vitamin E may antagonize vitamin K-dependent clotting and has antiplatelet effects, potentially raising INR and bleeding risk. Typical dietary doses rarely matter.
How serious is the interaction between Vitamin e and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose supplements; monitor INR when vitamin E intake changes.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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