Drug interactions
Apixaban + Caplacizumab
Severity: Major
Apixaban and Caplacizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and combined with apixaban it increases risk of significant bleeding.
What this interaction means in plain words
Apixaban and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of von Willebrand factor blockade and factor Xa inhibition.
What to do
Avoid combination where possible; if required, monitor closely for bleeding and consider holding apixaban.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Caplacizumab
Frequently asked questions
Can I take Apixaban with Caplacizumab?
MediHelp rates the interaction as major. Apixaban and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and combined with apixaban it increases risk of significant bleeding.
How serious is the interaction between Apixaban and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; if required, monitor closely for bleeding and consider holding apixaban.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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