Drug interactions
Apixaban + Cenobamate
Severity: Moderate
Apixaban and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate may induce CYP3A4 and lower apixaban exposure. This could reduce anticoagulant effect and raise the risk of thromboembolism.
What this interaction means in plain words
Apixaban and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4, increasing apixaban clearance.
What to do
Monitor for signs of thrombosis and reassess anticoagulant choice if events occur. Consider an anticoagulant less dependent on CYP3A4 and P-gp.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Apixaban with Cenobamate?
MediHelp rates the interaction as moderate. Apixaban and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate may induce CYP3A4 and lower apixaban exposure. This could reduce anticoagulant effect and raise the risk of thromboembolism.
How serious is the interaction between Apixaban and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of thrombosis and reassess anticoagulant choice if events occur. Consider an anticoagulant less dependent on CYP3A4 and P-gp.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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