Drug interactions
Apixaban + Factor x human
Severity: Major
Apixaban and Factor x human: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Human plasma-derived factor X is given to replace deficient factor X in hereditary deficiency. Apixaban inhibits activated factor X, so it can blunt the hemostatic benefit of the replacement product.
What this interaction means in plain words
Apixaban and Factor x human can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism, as apixaban directly inhibits the factor Xa generated from the infused factor X.
What to do
Avoid combining them. If factor X replacement is needed, hold apixaban and use an alternative anticoagulant if anticoagulation is still required, monitoring clinical response and factor X activity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Factor x human?
MediHelp rates the interaction as major. Apixaban and Factor x human can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Human plasma-derived factor X is given to replace deficient factor X in hereditary deficiency. Apixaban inhibits activated factor X, so it can blunt the hemostatic benefit of the replacement product.
How serious is the interaction between Apixaban and Factor x human?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them. If factor X replacement is needed, hold apixaban and use an alternative anticoagulant if anticoagulation is still required, monitoring clinical response and factor X activity.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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