Drug interactions
Apixaban + Fexinidazole
Severity: Moderate
Apixaban and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4, which could raise apixaban exposure. Higher apixaban levels increase the risk of bleeding.
What this interaction means in plain words
Apixaban and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated apixaban metabolism, which is predicted from in vitro data and not clearly established clinically.
What to do
Monitor for bleeding signs and hemoglobin during the short fexinidazole course. Consider an alternative anticoagulant if the patient has other bleeding risk factors such as renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Fexinidazole?
MediHelp rates the interaction as moderate. Apixaban and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4, which could raise apixaban exposure. Higher apixaban levels increase the risk of bleeding.
How serious is the interaction between Apixaban and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin during the short fexinidazole course. Consider an alternative anticoagulant if the patient has other bleeding risk factors such as renal impairment.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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