Drug interactions
Apixaban + Glecaprevir / pibrentasvir
Severity: Moderate
Apixaban and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir inhibit P-gp, and apixaban exposure may increase. The result could be a higher risk of bleeding.
What this interaction means in plain words
Apixaban and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein (and possibly BCRP) reduces apixaban efflux and clearance.
What to do
Monitor for bleeding during the HCV treatment course. Check renal function and consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Apixaban and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both glecaprevir and pibrentasvir inhibit P-gp, and apixaban exposure may increase. The result could be a higher risk of bleeding.
How serious is the interaction between Apixaban and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding during the HCV treatment course. Check renal function and consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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