Drug interactions
Apixaban + Meclofenamate
Severity: Major
Apixaban and Meclofenamate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that inhibits platelet function and can injure the gastric mucosa. With apixaban, the risk of gastrointestinal and other bleeding is increased.
What this interaction means in plain words
Apixaban and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bleeding risk from COX-mediated platelet inhibition and GI mucosal injury combined with factor Xa inhibition.
What to do
Avoid the NSAID where possible and use acetaminophen or another alternative. If unavoidable, use the lowest dose for the shortest time, add gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Meclofenamate?
MediHelp rates the interaction as major. Apixaban and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Meclofenamate is an NSAID that inhibits platelet function and can injure the gastric mucosa. With apixaban, the risk of gastrointestinal and other bleeding is increased.
How serious is the interaction between Apixaban and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID where possible and use acetaminophen or another alternative. If unavoidable, use the lowest dose for the shortest time, add gastroprotection and monitor for bleeding.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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