Drug interactions
Apixaban + Nefazodone
Severity: Moderate
Apixaban and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may increase apixaban exposure, raising bleeding risk. The effect is less than with combined strong CYP3A4 and P-gp inhibitors but can still be relevant.
What this interaction means in plain words
Apixaban and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated apixaban metabolism.
What to do
Monitor for bleeding and consider an alternative antidepressant. Reassess apixaban dose in patients with renal impairment, advanced age or low body weight.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Nefazodone?
MediHelp rates the interaction as moderate. Apixaban and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and may increase apixaban exposure, raising bleeding risk. The effect is less than with combined strong CYP3A4 and P-gp inhibitors but can still be relevant.
How serious is the interaction between Apixaban and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider an alternative antidepressant. Reassess apixaban dose in patients with renal impairment, advanced age or low body weight.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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