Drug interactions
Apixaban + Omacetaxine
Severity: Major
Apixaban and Omacetaxine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omacetaxine commonly causes severe thrombocytopenia, and apixaban further increases the risk of bleeding. Omacetaxine labeling advises avoiding anticoagulants when platelet counts are low.
What this interaction means in plain words
Apixaban and Omacetaxine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bleeding risk from drug-induced thrombocytopenia plus anticoagulation.
What to do
Avoid apixaban when platelets are below the label threshold and monitor blood counts often. Hold or adjust anticoagulation during severe thrombocytopenia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Frequently asked questions
Can I take Apixaban with Omacetaxine?
MediHelp rates the interaction as major. Apixaban and Omacetaxine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omacetaxine commonly causes severe thrombocytopenia, and apixaban further increases the risk of bleeding. Omacetaxine labeling advises avoiding anticoagulants when platelet counts are low.
How serious is the interaction between Apixaban and Omacetaxine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apixaban when platelets are below the label threshold and monitor blood counts often. Hold or adjust anticoagulation during severe thrombocytopenia.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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