Drug interactions
Apixaban + Venlafaxine
Severity: Moderate
Apixaban and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake and may increase bleeding when added to apixaban. Gastrointestinal bleeding is the main concern.
What this interaction means in plain words
Apixaban and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: SNRI-related platelet dysfunction plus factor Xa inhibition.
What to do
Monitor for bleeding signs and anemia; consider gastroprotection in high-risk patients. No routine apixaban dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Apixaban with Venlafaxine?
MediHelp rates the interaction as moderate. Apixaban and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake and may increase bleeding when added to apixaban. Gastrointestinal bleeding is the main concern.
How serious is the interaction between Apixaban and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and anemia; consider gastroprotection in high-risk patients. No routine apixaban dose change is needed.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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