Drug interactions
Aprotinin + Benazepril
Severity: Moderate
Aprotinin and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprotinin inhibits kallikrein and may blunt the blood-pressure-lowering effect of ACE inhibitors. It has also been associated with renal dysfunction, which may be worsened with ACE inhibitor use during cardiac surgery.
What this interaction means in plain words
Aprotinin and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprotinin inhibits kallikrein-kinin system activity, reducing bradykinin-mediated vasodilation of ACE inhibitors, and has direct renal effects.
What to do
Monitor blood pressure and renal function perioperatively. Follow local protocols on holding benazepril before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Aprotinin with Benazepril?
MediHelp rates the interaction as moderate. Aprotinin and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprotinin inhibits kallikrein and may blunt the blood-pressure-lowering effect of ACE inhibitors. It has also been associated with renal dysfunction, which may be worsened with ACE inhibitor use during cardiac surgery.
How serious is the interaction between Aprotinin and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function perioperatively. Follow local protocols on holding benazepril before surgery.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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