Drug interactions
Arformoterol + Candesartan-hydrochlorothiazide
Severity: Moderate
Arformoterol and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol can lower serum potassium, and hydrochlorothiazide adds renal potassium loss. The combination may cause significant hypokalemia and ECG changes, particularly at higher doses or with hypoxia.
What this interaction means in plain words
Arformoterol and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from beta-2 agonist intracellular potassium shift and thiazide-induced renal potassium excretion.
What to do
Check serum potassium and magnesium at baseline and periodically. Correct deficits, particularly in patients at risk of arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Arformoterol and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol can lower serum potassium, and hydrochlorothiazide adds renal potassium loss. The combination may cause significant hypokalemia and ECG changes, particularly at higher doses or with hypoxia.
How serious is the interaction between Arformoterol and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically. Correct deficits, particularly in patients at risk of arrhythmia.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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