Drug interactions
Arformoterol + Fluoxetine
Severity: Moderate
Arformoterol and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fluoxetine and the beta-agonist arformoterol can prolong the QT interval, and beta-agonists can also lower potassium. Together they may increase the risk of ventricular arrhythmia, mainly in patients with cardiac disease.
What this interaction means in plain words
Arformoterol and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with beta-agonist-induced hypokalemia as a further contributor.
What to do
Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Use the lowest effective arformoterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Fluoxetine?
MediHelp rates the interaction as moderate. Arformoterol and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both fluoxetine and the beta-agonist arformoterol can prolong the QT interval, and beta-agonists can also lower potassium. Together they may increase the risk of ventricular arrhythmia, mainly in patients with cardiac disease.
How serious is the interaction between Arformoterol and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Use the lowest effective arformoterol dose.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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