Drug interactions
Arformoterol + Fosinopril-hydrochlorothiazide
Severity: Moderate
Arformoterol and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol, a long-acting beta-2 agonist, can lower serum potassium and thiazides add to this effect. Hypokalemia may promote arrhythmias and ECG changes, particularly in patients with hypoxia or heart disease.
What this interaction means in plain words
Arformoterol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from thiazide renal potassium wasting and beta-2 agonist-induced intracellular potassium shift.
What to do
Check serum potassium and magnesium at baseline and periodically during combined therapy, and correct deficits. Take extra care in patients with cardiac disease or hypoxia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Arformoterol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol, a long-acting beta-2 agonist, can lower serum potassium and thiazides add to this effect. Hypokalemia may promote arrhythmias and ECG changes, particularly in patients with hypoxia or heart disease.
How serious is the interaction between Arformoterol and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically during combined therapy, and correct deficits. Take extra care in patients with cardiac disease or hypoxia.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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