Drug interactions
Arformoterol + Maprotiline
Severity: Major
Arformoterol and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants of the tricyclic type can potentiate the cardiovascular effects of long-acting beta-agonists, including QT prolongation, tachyarrhythmia and blood pressure changes. The label for arformoterol advises caution with such agents.
What this interaction means in plain words
Arformoterol and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive adrenergic and QT-prolonging effects on the cardiovascular system.
What to do
Use only if the benefit outweighs the risk and monitor heart rate, ECG and potassium. Consider an alternative antidepressant in patients with arrhythmia risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Maprotiline?
MediHelp rates the interaction as major. Arformoterol and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antidepressants of the tricyclic type can potentiate the cardiovascular effects of long-acting beta-agonists, including QT prolongation, tachyarrhythmia and blood pressure changes. The label for arformoterol advises caution with such agents.
How serious is the interaction between Arformoterol and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if the benefit outweighs the risk and monitor heart rate, ECG and potassium. Consider an alternative antidepressant in patients with arrhythmia risk.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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