Drug interactions
Arformoterol + Nebivolol
Severity: Moderate
Arformoterol and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can oppose the bronchodilator action of long-acting beta-2 agonists such as arformoterol, and may precipitate bronchospasm in patients with airway disease. Nebivolol's beta-1 selectivity lowers but does not eliminate this risk.
What this interaction means in plain words
Arformoterol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Competitive pharmacodynamic antagonism at beta adrenergic receptors, with loss of selectivity at higher nebivolol doses.
What to do
Monitor respiratory status and heart rate, keep the nebivolol dose low, and consider an alternative to beta-blockade in patients with significant bronchospasm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Nebivolol?
MediHelp rates the interaction as moderate. Arformoterol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can oppose the bronchodilator action of long-acting beta-2 agonists such as arformoterol, and may precipitate bronchospasm in patients with airway disease. Nebivolol's beta-1 selectivity lowers but does not eliminate this risk.
How serious is the interaction between Arformoterol and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and heart rate, keep the nebivolol dose low, and consider an alternative to beta-blockade in patients with significant bronchospasm.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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