Drug interactions
Argatroban + Azapropazone
Severity: Moderate
Argatroban and Azapropazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azapropazone is an NSAID that impairs platelet function and can injure the gastrointestinal mucosa, so combining it with a direct thrombin inhibitor raises the likelihood of clinically significant bleeding. Protein binding displacement is a minor contributor at most.
What this interaction means in plain words
Argatroban and Azapropazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect from NSAID platelet inhibition and GI mucosal injury combined with thrombin inhibition.
What to do
Avoid the NSAID where possible, or monitor aPTT and watch for gastrointestinal or other bleeding. Consider gastroprotection if the combination is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Azapropazone?
MediHelp rates the interaction as moderate. Argatroban and Azapropazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azapropazone is an NSAID that impairs platelet function and can injure the gastrointestinal mucosa, so combining it with a direct thrombin inhibitor raises the likelihood of clinically significant bleeding. Protein binding displacement is a minor contributor at most.
How serious is the interaction between Argatroban and Azapropazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID where possible, or monitor aPTT and watch for gastrointestinal or other bleeding. Consider gastroprotection if the combination is unavoidable.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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