Drug interactions
Argatroban + Butabarbital
Severity: Minor
Argatroban and Butabarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate and CYP enzyme inducer that could in theory lower argatroban exposure. Argatroban is mainly cleared by hepatic metabolism, but CYP3A4/5 makes only a minor contribution, so the clinical effect is probably small.
What this interaction means in plain words
Argatroban and Butabarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible enzyme induction increasing hepatic metabolism of argatroban; clinical relevance is uncertain.
What to do
No routine change is needed. Titrate argatroban to aPTT and check for reduced anticoagulant effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Butabarbital?
MediHelp rates the interaction as minor. Argatroban and Butabarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital is a barbiturate and CYP enzyme inducer that could in theory lower argatroban exposure. Argatroban is mainly cleared by hepatic metabolism, but CYP3A4/5 makes only a minor contribution, so the clinical effect is probably small.
How serious is the interaction between Argatroban and Butabarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Titrate argatroban to aPTT and check for reduced anticoagulant effect.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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