Drug interactions
Argatroban + Butalbital
Severity: Minor
Argatroban and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing properties that could theoretically lower argatroban exposure. Because CYP3A4/5 plays only a minor role in argatroban clearance, a significant effect is unlikely.
What this interaction means in plain words
Argatroban and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible enzyme induction increasing hepatic metabolism of argatroban; clinical relevance is uncertain.
What to do
No routine change is needed. Titrate argatroban to aPTT and check for reduced anticoagulant effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Butalbital?
MediHelp rates the interaction as minor. Argatroban and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with enzyme-inducing properties that could theoretically lower argatroban exposure. Because CYP3A4/5 plays only a minor role in argatroban clearance, a significant effect is unlikely.
How serious is the interaction between Argatroban and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Titrate argatroban to aPTT and check for reduced anticoagulant effect.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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