Drug interactions
Argatroban + Cefamandole
Severity: Moderate
Argatroban and Cefamandole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole can cause hypoprothrombinemia and may impair platelet function, which adds to the anticoagulant effect of argatroban. Bleeding risk may be increased, particularly in malnourished or critically ill patients.
What this interaction means in plain words
Argatroban and Cefamandole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: cefamandole's N-methylthiotetrazole side chain interferes with vitamin K-dependent clotting factor synthesis.
What to do
Monitor aPTT and INR (argatroban itself raises INR) and watch for bleeding. Consider an alternative antibiotic without this effect if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Cefamandole?
MediHelp rates the interaction as moderate. Argatroban and Cefamandole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefamandole can cause hypoprothrombinemia and may impair platelet function, which adds to the anticoagulant effect of argatroban. Bleeding risk may be increased, particularly in malnourished or critically ill patients.
How serious is the interaction between Argatroban and Cefamandole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT and INR (argatroban itself raises INR) and watch for bleeding. Consider an alternative antibiotic without this effect if bleeding risk is high.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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