Drug interactions
Argatroban + Citalopram
Severity: Moderate
Argatroban and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram impairs platelet function and may increase bleeding when used with the direct thrombin inhibitor argatroban. The risk is additive rather than pharmacokinetic.
What this interaction means in plain words
Argatroban and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Citalopram belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion adds to the anticoagulant effect of argatroban.
What to do
Monitor for signs of bleeding and follow aPTT or other coagulation tests as usual for argatroban dosing. Reassess the need for the SSRI in patients with high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Citalopram?
MediHelp rates the interaction as moderate. Argatroban and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram impairs platelet function and may increase bleeding when used with the direct thrombin inhibitor argatroban. The risk is additive rather than pharmacokinetic.
How serious is the interaction between Argatroban and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and follow aPTT or other coagulation tests as usual for argatroban dosing. Reassess the need for the SSRI in patients with high bleeding risk.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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