Drug interactions
Argatroban + Devil's claw
Severity: Moderate
Argatroban and Devil's claw: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has been linked to bleeding and altered coagulation in case reports, and may have mild antiplatelet effects. Combined with argatroban it could add to bleeding risk, though the evidence is limited.
What this interaction means in plain words
Argatroban and Devil's claw can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive antiplatelet or anticoagulant effect; the mechanism is not well established.
What to do
Discourage use of devil's claw during anticoagulation. Monitor for bleeding and aPTT if the combination continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Devil's claw?
MediHelp rates the interaction as moderate. Argatroban and Devil's claw can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Devil's claw has been linked to bleeding and altered coagulation in case reports, and may have mild antiplatelet effects. Combined with argatroban it could add to bleeding risk, though the evidence is limited.
How serious is the interaction between Argatroban and Devil's claw?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage use of devil's claw during anticoagulation. Monitor for bleeding and aPTT if the combination continues.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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